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SONIC: Subcallosal Cingulate DBS for Treatment-Resistant Depression (NCT03437928)

ClinicalTrials.gov · April 1, 2026

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Multicenter trial of subcallosal cingulate white matter DBS in 60 severely treatment-resistant depression patients across 6 US sites, using diffusion tractography-guided targeting to identify the optimal stimulation site per individual. Extends Emory's…

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Deep Brain StimulationDepressionMental Health TechNeuroimagingPhase 2