Research Paper
Deep brain stimulation surgical timing, outcomes, and prognostic factors in patients with Parkinson's disease: A Chinese retrospective multicenter cohort study
PLOS ONE1/8/2025·01/08/25🌐 Asia
Summary
This multicenter Chinese cohort study examined DBS outcomes across different Parkinson's disease durations. Motor, neuropsychological, and quality-of-life improvements were observed across all disease durations, with the most substantial benefits in mid-duration patients. Levodopa response was a consistent positive prognostic factor.
Why it matters
The finding that surgical timing affects DBS outcomes has direct clinical implications for referral patterns. The identification of levodopa response as a key prognostic factor supports existing practices while highlighting caution for short-duration patients with rapidly progressive symptoms.
#Deep Brain Stimulation#Parkinson's#Neurostimulation#Neuroprosthetics
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