Neuromodulation Treatments Targeting Pathological Synchrony for Tinnitus in Adults: A Systematic Review
Summary
This systematic review evaluated neuromodulation therapies for tinnitus that explicitly target pathological synchronous neural activity. Across 24 included randomized controlled trials, tDCS demonstrated significant improvement in tinnitus symptom severity versus control, although heterogeneity was high. Fewer trials of acoustic, vagal nerve, or tACS stimulation showed limited evidence of effectiveness.
Why it matters
Pathological neural synchrony is a key mechanism underlying tinnitus. This review consolidates evidence for neuromodulation approaches that directly target this synchrony, finding tDCS to have the strongest evidence base. The high heterogeneity highlights the need for standardized stimulation parameters and better patient selection criteria to optimize treatment outcomes.
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