A Closed-Loop-Capable Neural Interface Platform for Deep Brain Modulation via Integrated Non-Viral Gene Delivery, NIR Optogenetics, and Electrophysiological Recording

Summary

This study reported a multifunctional neural interface integrating non-viral delivery of Channelrhodopsin-2 gene plasmid, fiberless intracranial optogenetic stimulation via near-infrared excitation, and electrophysiological recording into a single implantable device. In vivo implantation into the hippocampal dentate gyrus demonstrated successful opsin expression and real-time light-evoked neural activity via single surgical step.