Repetitive and extensive focused ultrasound-mediated bilateral frontal blood-brain barrier opening for Alzheimer's disease
Summary
This open-label prospective study enrolled 6 AD patients for FUS-mediated BBB opening performed three times at 2-month intervals targeting bilateral frontal lobes. All participants completed the study without acute adverse events. FBB-PET scans demonstrated a 14.9-Centiloid average decrease in amyloid-beta plaques in 4 of 6 participants, and caregiver-reported neuropsychiatric symptoms improved in 5 of 6 participants.
Why it matters
This is the first clinical trial to demonstrate improvement in neuropsychiatric symptoms through BBB opening alone, without concurrent antibody medication. The repeated, more extensive bilateral frontal approach shows that multiple FUS sessions can be safely administered and may provide cumulative benefit for amyloid clearance and behavioral symptoms in AD.
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