Research Paper
Characterizing the effects of vagus nerve stimulation on symptom improvement in markedly treatment-resistant major depressive disorder: A RECOVER trial report
Journal of Affective Disorders7/1/2025·07/01/25🌐 USA
Summary
This report from the RECOVER trial examined alternative outcome metrics for VNS in markedly treatment-resistant depression. Partial response classification and 10-12 month observation periods showed greater sensitivity than remission or shorter periods, yielding significant treatment differences.
Why it matters
The finding that outcome metrics and observation periods substantially influence trial results has broad implications for neuromodulation clinical trial design. It suggests that conventional approaches may underestimate treatment effects in highly treatment-resistant populations.
#Depression#Mental Health Tech#Neurostimulation#FDA
Want the full NeurotechMag Pro intelligence database?
Access 800+ papers, trials, patents, funding rounds and news items — updated daily.
Start free trialAlready a member? Sign in