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Research Paper

Implantable peripheral nerve stimulation for chronic pain: a systematic review and meta-analysis of analgesic outcomes up to 24 months

Regional Anesthesia and Pain Medicine5/11/2025ยท05/11/25๐ŸŒ USA

Summary

This systematic review and meta-analysis included 106 studies with 9,272 patients evaluating implantable PNS for chronic pain. Large, statistically significant reductions in pain intensity were observed at all time points through 24 months, with the largest effect sizes in pelvic and upper extremity pain conditions.

Why it matters

The magnitude and durability of PNS analgesic effects across diverse pain conditions support broader clinical adoption and payer coverage. This comprehensive synthesis provides the evidence base needed to establish PNS as a standard-of-care neuromodulation option.

#Chronic Pain#Neurostimulation#Neural Interfaces#Neurodiagnostics

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