Research Paper
Optogenetic modulation of long-range cortical circuits in awake nonhuman primates
Nature Protocols8/1/2025·08/01/25🌐 USA
Summary
This protocol describes the combination of optogenetic stimulation with electrophysiological recordings in awake nonhuman primates to monitor and manipulate short- and long-range cortical circuits. The approach enables investigation of feedforward and feedback connections at various cortical distances during complex cognitive behavioral tasks.
Why it matters
Understanding causal connectivity in primate brains is essential for developing better neuromodulation therapies. This optogenetic approach in NHPs bridges the gap between rodent circuit studies and human applications, potentially guiding target selection for DBS and other interventions.
#Optogenetics#Neural Recording#Neuroimaging#Research Tools#Neural Interfaces
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