Research Paper
Comparison of percutaneous 60-day peripheral nerve stimulation of the lumbar medial branches to usual care with standard interventional management for chronic low back pain-a multicenter pragmatic randomized controlled trial (RESET)
Pain Medicine1/4/2026·01/04/26🌐 USA
Summary
The RESET trial randomized 230 patients with chronic low back pain to percutaneous 60-day PNS versus usual care. At 3 months, 55% of PNS patients achieved at least 50% pain relief compared to 26% in the usual care group, with sustained benefits through 6 months.
Why it matters
This pragmatic RCT provides high-quality evidence for temporary percutaneous PNS as an effective intermediate option before permanent implantation. The 60-day duration offers a reversible trial period that could improve patient selection for long-term neuromodulation.
#Chronic Pain#Neurostimulation#Non-invasive#Neural Interfaces
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