Research Paper
Deep Brain Stimulation to the Subgenual Cingulate Gyrus for Treatment-Resistant Depression: A Randomized Controlled Trial and 2-Year Long-Term Follow-Up
Canadian Journal of Psychiatry4/1/2026·04/01/26🌐 Europe
Summary
This largest single-center sham-controlled study of subcallosal cingulate DBS for treatment-resistant depression randomized 35 participants to a 6-month crossover trial followed by 18-month open-label follow-up. While the RCT showed no significant group differences, open-label response rates reached 65-73% at 12-24 months.
Why it matters
The discrepancy between sham-controlled and open-label outcomes highlights challenges in DBS trial design for depression. The findings inform future trial optimization, including contact selection for white matter tract engagement and longer observation periods to account for nonspecific surgical effects.
#Deep Brain Stimulation#Depression#Mental Health Tech#Neurostimulation
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