Repeated neuromodulation with low-intensity focused ultrasound in patients with Alzheimer's disease
Summary
This pilot study evaluated 10 early-stage Alzheimer's disease patients who underwent six sessions of neuronavigation-guided focused ultrasound targeting the left dorsolateral prefrontal cortex. Memory performance and functional connectivity between the left DLPFC and perirhinal cortex significantly improved from baseline. No adverse events were reported during treatment or follow-up.
Why it matters
Alzheimer's disease lacks effective symptomatic treatments beyond cholinesterase inhibitors. This pilot trial suggests focused ultrasound may enhance memory through network connectivity changes, warranting larger sham-controlled trials and potentially offering a new non-pharmacological approach to cognitive enhancement.
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