Research Paper

Deep brain stimulation for obsessive-compulsive-disorder: a systematic review and meta-analysis of individual participant outcome data from sham-controlled trials

Molecular Psychiatry10/1/2025·10/01/25🌐 Europe

Summary

This first meta-analysis using individual participant data from sham-controlled RCTs evaluated DBS for treatment-refractory obsessive-compulsive disorder. Nine RCTs with 91 patients showed a decrease of 5.1 YBOCS points favoring DBS over sham, with an odds ratio of 4.7 and number needed to treat of 3.9. Trials using gradual parameter optimization showed better outcomes.

Why it matters

OCD affects millions worldwide and many patients do not respond to conventional treatments. This rigorous meta-analysis strengthens the evidence base for DBS as a therapeutic option, potentially supporting regulatory approvals and expanded insurance coverage for this debilitating condition.

#Deep Brain Stimulation#OCD#Neurostimulation#Mental Health Tech#Research Tools

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