Clinical Trial
SONIC: Subcallosal Cingulate DBS for Treatment-Resistant Depression (NCT03437928)
ClinicalTrials.gov4/1/2026·04/01/26🌐 USA
Summary
Multicenter trial of subcallosal cingulate white matter DBS in 60 severely treatment-resistant depression patients across 6 US sites, using diffusion tractography-guided targeting to identify the optimal stimulation site per individual. Extends Emory's pioneering SCC DBS work with a standardized tractography-based surgical protocol.
Why it matters
SCC DBS has shown remarkable antidepressant effects in open-label series but mixed pivotal trial results. Tractography-based precision targeting may resolve the inconsistency if targeting variability was driving previous negative results.
#Deep Brain Stimulation#Depression#Mental Health Tech#Neuroimaging#Phase 2
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