Clinical Trial
Modulation of the Motor Pathway by Transcranial Pulse Stimulation in People With ALS: a Pilot Randomized Trial
ClinicalTrials.gov10/24/2024·10/24/24🌐 Europe
Summary
This trial evaluates transcranial pulse stimulation (TPS) for modulating the motor pathway in patients with amyotrophic lateral sclerosis. Using the NEUROLITH device, the study delivers low-intensity ultrasound pulses to the motor cortex to reduce cortical hyperexcitability and potentially slow upper motor neuron degeneration.
Why it matters
TPS is a novel neuromodulation modality using ultrasound that can penetrate deeper than TMS or tDCS. If effective in reducing cortical hyperexcitability in ALS, it could become the first disease-modifying device therapy that targets a key pathophysiological mechanism in motor neuron degeneration.
#Phase 2#ALS#Neurostimulation#Focused Ultrasound#Non-invasive#Neurodiagnostics#Europe
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