Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions
Summary
This narrative review provides an up-to-date overview of low-intensity transcranial focused ultrasound (tFUS) for psychiatric applications. The review covers main system components, neuronavigational tools for targeting deep brain regions, simulation tools for optimizing parameters, and experimental protocols. Key findings from studies in depression, anxiety, and schizophrenia are presented and discussed.
Why it matters
Psychiatric disorders represent a major unmet need where existing treatments often fail. tFUS offers unique advantages over other non-invasive brain stimulation methods by reaching deep subcortical structures with millimetric precision. This review synthesizes the nascent but promising evidence for tFUS in psychiatry, guiding future clinical trial design and regulatory pathways.
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