Targeting thalamocortical circuits for closed-loop stimulation in Lennox-Gastaut syndrome
Summary
This paper outlines the therapeutic rationale and neurosurgical targeting for bilateral, closed-loop, thalamocortical stimulation in Lennox-Gastaut syndrome. By synthesizing multi-modal brain network maps from EEG-fMRI, PET, and diffusion MRI, the authors identified bilateral premotor cortex as a key cortical hotspot. A prospective, multi-centre trial of this dual-target approach is currently underway.
Why it matters
Lennox-Gastaut syndrome is a severe childhood-onset epilepsy that is often refractory to medication. This work advances a novel dual-target closed-loop stimulation approach combining thalamic and cortical targets, which may allow more rapid seizure detection and broader modulation of the epileptic network compared to thalamus-only approaches.
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