Research Paper

Deep Brain Stimulation for Disorders of Consciousness: An Individual Patient Data Meta-Analysis

Neuromodulation4/1/2026·04/01/26🌐 Asia

Summary

This individual patient data meta-analysis of 81 patients across nine studies found that DBS conferred modest improvements in conscious awareness for disorders of consciousness. The pooled mean CRS-R improvement was 2.15 points, with 30.9% transitioning to a higher consciousness category.

Why it matters

Despite limited therapeutic benefits and substantial risks, DBS shows promise for selected patients with disorders of consciousness. This analysis supports development of rigorous patient selection frameworks and standardized protocols to guide clinical decision-making in this challenging population.

#Deep Brain Stimulation#Neurostimulation#Neuroprosthetics#Neural Interfaces

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