Resting-state EEG signatures of Alzheimer's disease are driven by periodic but not aperiodic changes
Summary
This study examined whether resting-state EEG changes in Alzheimer's disease reflect true oscillatory (periodic) changes, changes in the aperiodic (non-oscillatory) signal, or both. Across two independent datasets, alterations were found to be purely periodic in nature, with decreases in oscillatory power at alpha and beta frequencies in AD. Aperiodic EEG features did not differ between AD and healthy controls.
Why it matters
This finding clarifies the mechanism underlying EEG alterations in Alzheimer's disease, providing robust evidence for purely oscillatory pathophysiology. The results emphasize the robustness of oscillatory AD signatures, which can serve as potential prognostic or interventional targets in clinical investigations, helping to refine EEG-based diagnostic approaches.
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